- Title
- Synaptic plasticity based model for epileptic seizures
- Creator
- Alamir, Mazen; Welsh, James S.; Goodwin, Graham C.
- Relation
- Automatica Vol. 47, Issue 6, p. 1183-1192
- Publisher Link
- http://dx.doi.org/10.1016/j.automatica.2011.02.018
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2011
- Description
- In this paper, a new dynamic model describing the epileptic seizure initiation through transition from interictal to ictal state in a brain predisposed to epilepsy is suggested. The model follows Freeman’s approach where the brain is viewed as a network of interconnected oscillators. The proposed nonlinear model is experimentally motivated and relies on changes in synaptic strength in response to excitatory spikes. This model exhibits a threshold beyond which a bifurcation toward a short-term plasticity state occurs leading to seizure onset. A resulting explanatory assumption is that when considering epilepsy, brain regions are characterized by abnormally low thresholds toward short-term synaptic plasticity. It is shown by simulation that the proposed model enables some experimentally observed qualitative features to be reproduced. Moreover, a preliminary discussion on the impact of the underlying assumptions on the fundamental issue of seizure control is proposed through an EEG based feedback control scheme.
- Subject
- oscillator network; dynamic modeling; synaptic strength; synchronization; epileptic seisures
- Identifier
- http://hdl.handle.net/1959.13/936559
- Identifier
- uon:12343
- Identifier
- ISSN:0005-1098
- Language
- eng
- Reviewed
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